Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-Immune System (NEIS). 2d Ed. Part 2.

OBJECTIVES

The second part of the course will focus on the inter-relationship with cranial nerve V, VII, IX and X. Further we will dig more into neuro-immunology, especially how inflammation reaches and spreads inside the brain, leading to specific neurotransmitters imbalance and depletion along with excito-neurotoxicity. We will see how key neurohormones interfere with neurotransmission and body neuroimmune processes. We will review the applied osteopathic general and specifically orientated treatment to target the neuroendocrine-immune system and the ANS. We will introduce bioelectronic medicine as a tool that can be used as well in our patient management system. We will review the rationale behind the use of safe non-invasive vagus and trigeminal nerve stimulation and their effects of the sympatho-vagal balance as demonstrated by HRV analysis.

Heart rate variability analysis will be performed before and after treatment (osteopathy and electrical nerve stimulation.

At the end of the course Part 2, the participant will be able to:

• Understand the essentials relationships with cranial nerve V, VII, IX and the Vagus nerve.
• Understand the Blood-Brain-Barrier related to immunology.
• Understand the role of the Glia in immune responses.
• Understand the importance of Gateway reflexes in immunology.
• Understand the role of the key neurohormones in immunology.
• Review and process Heart Rate Variability analysis based on a 3-lead ECG.
• Review and conduct a patient-centred osteopathic treatment to modify the sympatho-vagal balance.
• Understand the principle of non-invasive vagus nerve stimulation and its effects on the sympatho-vagal balance through the modulation of the central autonomic network via specific modulation parameters.
• Conduct an HRV analysis based on short-term ECG.
• Decide what best treatment, based on patient symptomatology, detailed case history and any other valuable information (like paraclinical assessments), would be the most efficient, if rationale and safe treatment can be conducted.

Content Part 2:

•  Applied anatomy: cranial nerves V, VII et IX

•  Inflammation and the blood brain barrier

•  Glia: Immune role

•  The GATEWAY reflexes

•  Key neurohormones in immunology and neurotransmission

•  Scientific evidence and indications of non-invasive vagus and the trigeminal nerve stimulation (nVNS and nTNS)

•  Applied osteopathic treatment (continue from Part 1) and HRV analysis

•  Vagus nerve and trigeminal nerve stimulation: indications, contraindications, stimulation parameters

•  Vagus nerve and trigeminal nerve stimulation: exercises

•  HRV analysis exercises before and after stimulation

•  Treatment protocols for nVNS and nTNS: case review and exercise

•  Other natural means to stimulate the vagus and the trigeminal nerve

Who Should Attend This Course

Participants of Part 1 (Ed.1 or Ed.2)

The course will be given at Legge Clinic, in Truro, Nova Scotia.

CEUs EARNED: 21h-equivalent at the end of part 2 with a certificate issued at the end of the course.

Early birds enrolling up before Nov. 30th : use the coupon code: NEISX22d to get a 15% discount!

Note: language will be English with French translation if needed.

·  Cancellation deadline: 4 weeks before

SELECTED READINGS

Tracey, K. J. (2002). "The inflammatory reflex." Nature 420(6917): 853-859.

Hosoi, T. and Y. Nomura (2004). "Functional role of acetylcholine in the immune system." Frontiers in Bioscience 9: 2414-2419.

Rosas-Ballina, M., et al. (2008). "Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia." Proceedings of the National Academy of Sciences of the United States of America 105(31): 11008-11013.

d.  Sundman, E. and P. S. Olofsson (2014). "Neural control of the immune system." Advances in Physiology Education 38(2): 135-139.

Chavan, S. S. and K. J. Tracey (2017). "Essential Neuroscience in Immunology." Journal of Immunology 198(9): 3389-3397.

Ventureyra, E. C. (2000). "Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept." Child's Nervous System 16(2): 101-102.

Howland, R. H. (2014). "Vagus Nerve Stimulation." Curr Behav Neurosci Rep 1(2): 64-73.

Dietrich, S., et al. (2008). "[A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI]." Biomedizinische Technik 53(3): 104-111.

Das, U. N. (2007). "Vagus nerve stimulation, depression, and inflammation." Neuropsychopharmacology 32(9): 2053-2054.

Miller, M. C. (2006). "What is vagus nerve stimulation?" Harvard Mental Health Letter 22(7): 8.

Buschman, H. P., et al. (2006). "Heart rate control via vagus nerve stimulation." Neuromodulation 9(3): 214-220.

Hirsch, E. F. (1962). "Innervation of the human heart. III. The conductive system." Archives of Pathology 74: 427-439.

Voss, A., et al. (2015). "Short-term heart rate variability--influence of gender and age in healthy subjects." PloS One 10(3): e0118308.

Mion, F., Pellissier, S., Garros, A., Damon, H., Roman, S., & Bonaz, B. (2020). Transcutaneous auricular vagus nerve stimulation for the treatment of irritable bowel syndrome: a pilot, open-label study. Bioelectronics in Medicine.doi:10.2217/bem-2020-0004

Bezilla T. The Effects on Stress on the Hypothalamus and Neuro Endocrine System. An Osteopathic Perspeceve. In:

Osteopathy TI of C, editor. Yearbook - A Colleceon of Arecles, Lectures and Essays. 2018. p. 138–55

Baden C. Physiological Principles in the Classical Osteopathic Treatment of Disease. In: The Insetute of Classical

Osteopathy, Dorking U, editor. Yearbook. 1st Edieo. 2018. p. 64–99

Lidlejohn JM, Meyran, LS. Principles of Osteopathy. JM Lidlejohn Lectures notes. Chicago, IL. American College of

Osteopathic Medicine and Surgery. 191141

Burns L. Studies in Osteopathic Sciences, the Nerve Centres. Vol II. 1911.

Pascal J.D. Grolaux, Timothy J. Sparrow, François Lalonde; Traditional Osteopathy and the General Osteopathic Treatment: A Historical Concept and a Modern Application. AAO Journal 1 December 2021; 31 (4): 39–46. doi: https://doi.org/10.53702/2375-5717-31.4.39

Grolaux P.J.D. (2019). Transcutaneous Vagus Nerve Stimulation in Private Healthcare Center: A Small-Scale Investigation Targeting Anxiety, Irritable Bowel Syndrome and Chronic Pain. J Neurol Neuromed 4(5): 7-22

Pascal J.D. Grolaux. Effects of Chronic Non-Invasive Vagus Nerve Stimulation in an Asplenic Individual with Rheumatoid Arthritis: Report from an n-of-1 Study., 12 April 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1546549/v1]