Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-Immune System (NEIS). 2d Ed. Part 2.

Pascal JD Grolaux, BSc, DO, MOst. Dr. (hon) ACoPM will offer the unique, evidence-based and most comprehensive course, so far proposed in Canada and in Europe, on the Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS), including Heart Rate Variability analysis based on short-term EKG and learning on bioelectronic medicine (non-invasive vagus nerve and trigeminal nerve stimulation based on latest scientific evidences).

OBJECTIVES

The Part 2 of the course (Webinar) (only for those who have followed the Part 1), will give you an introduction about other key cranial nerves in relation with the vagus nerve, it will teach you more on neuroendocrine immunology, the blood-brain-barrrier and brain inflammation mecanisms. We will see key neurohormones in immunology in relation to the vagus nerve and inflammation, how pain, gravity and stress can trigger inflammation and spread into the brain via gateway reflexes. Finally we will talk about heart rate variability (HRV) analysis and how we best can assess the sympatho-vagal balance. HRV is a validated biomarker predicting psychophysiological and general physiological processes. HRV is a simple mean to assess the global health status of your patients/clients and to see the progress they make in their health recovery, or just simply to make sure they keep staying on the healthy side.

At the end of the course "“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 2”, the partiipant will be able to:

• Understand the essentials relationships with cranial nerve V, VII, IX and the Vagus nerve
• Understand the Blood-Brain-Barrier related to immunology
• Understand the role of the Glia in immune responses
• Understand the importance of the Gateway relfexes in immunology
• Understand the role of the key neurohormones in immunology
• Understand the principles of Heart Rate Variability Analysis based on a 3-lead EKG

Who Should Attend This Course

This course is designed for Osteopaths, and other Health Practitioners who has followed the previous Part 1 of the course.

• Part 2 is a webinar (theory only) for all participants from the Part 1.
• Part 3 and Part 4 will be onsite 2 days practice only each and is divided in two possibilities (2 days each) 1. Applied osteopathic treatment (only for Osteopathic manual practitioner). 2. Non-invasive vagus nerve (tVNS) and trigeminal nerve stimulation (tTMS) (for Osteopathic manual practitioner, and other Health Professionals).

Note that only Osteopathic manual practitioner can enroll to the 4 days practice (OMT and tVNS-tTMS)!

A zoom link will be sent to the participants at least the day before the start of the webinar.

The webinar will be recorded and be accessible for further free viewing to the registered participants without expiration time.

TOTAL CEUs EARNED at the end of the full course : either 39.5 hours CEUs including 2 days practice ( osteo or neuromodulation) or 54 hours CEUs including 4 days practice (osteo + neuromodulation), with a certificate issued at the end of the course (with a minimum of 3 parts completed).

Note: language will be English with French translation if needed.

WEBINAR PROGRAM (PART 2).

Second Webinar (Theory): 3days with 5hours each (total 15h)

“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 2”

·  Type: Live webinar recorded for further use

·  Language: English

·  Participants: Osteopaths, other Health Practitioners

·  Date : 12-14 January 2024

·  Duration: 3 days with 5 hours each (one additional hour might be required)

·  Schedule: 10:00am-3:00 pm, local time (Maritimes - Halifax)

·  Cancellation deadline: 4 weeks before

·  Prerequisite: “Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 1.”

·  Precondition for practical course “Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System” and/or “Osteopathic Approach Targeting the Vagus nerve and the Neuroendocrine-immune system”

Content Webinar Part 2:

•  APPLIED ANATOMY : CRANIAL NERVES V, VII et IX

•  INFLAMMATION AND THE BLOOD BRAIN BARRIER

•  GLIA: IMMUNE RESPONSE

•  THE GATEWAY REFLEXES

•  NEUROHORMONES IN IMMUNOLOGY

•  HEART RATE VARIABILITY: PRINCIPLES AND ANALYSIS

IIIa: Part 3. Practical course: 2-day onsite in Truro, NS

Osteopathic Approach Targeting the Vagus nerve and the Neuroendocrine-immune system

·  Type: Practical course at IOSR - Truro, NS

·  Language: English-French translation available if needed

·  Participants: Osteopaths

·  Date:  April 19-20 - 2024

·  Duration: 2 full days

·  Schedule:  Friday/Saturday: 9AM-5PM

.  CEU earned: 14.5 hours

·  Cancellation deadline: 4 weeks before course

·  Precondition: Webinar 1 and 2 must have been completed

Content practice Part 3:

•  Practical: Bringing your own ECG (like eMotion Faros 180) with Kubios installed is not a prerequisite but recommended.

·  Philosophy and Principles behind the NEI osteopathic treatment approach

·  The Osteopathic Centers and the principle of inhibition

·  Applied General and Specific Osteopathic approaches/techniques evaluated by ECG/HRV analysis

·  Heart rate variability analysis (with Kubios software) and assessment of the sympatho-vagal balance via short-term 3 leads EKG, before and after the treatment

·  Other natural means to stimulate the vagus and trigeminal nerves

·  Discussion

IIIb: Part 4. Practical course: 2-day onsite in Truro, NS

„Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System “

·  Type: Practical course at IOSR - Truro, NS

·  Language: English-French translation available if needed

·  Participants: Osteopaths, other Health Practitioners

·  Date: April 21-22 - 2024

·  Duration: 2 full days

·  Schedule: Sunday/Monday. (9AM-5PM)

.  CEU earned: 14.5 hours

·  Cancellation deadline: 4 weeks before course

·  Precondition: Webinar Part 1 and Part 2 must have been completed

Content practice Part 4:

•  Practical: Bringing your own ECG (like eMotion Faros 180) with Kubios installed is not a prerequisite but recommended.

•  Theory: History/principles of Neuromodulation

•  Neuromodulation - demonstration: X, V nerves

•  Scientific evidences and indications of non-invasive vagus and the trigeminal  nerve stimulation (nVNS and nTNS)

•  Heart rate variability and assessment of the sympatho-vagal balance via short-term 3 leads ECG, analysis via Kubios software.

•  Vagus nerve and trigeminal nerve stimulation : indications and contraindications

•  Vagus nerve and trigeminal nerve stimulation : exercices

•  HRV analysis exercices before and after stimulation

•  Treatment protocols for nVNS and nTNS: case review and exercise

•  Other natural means to stimulate the vagus and trigeminal nerves

•  Discussion

SELECTED READINGS

Tracey, K. J. (2002). "The inflammatory reflex." Nature 420(6917): 853-859.

Hosoi, T. and Y. Nomura (2004). "Functional role of acetylcholine in the immune system." Frontiers in Bioscience 9: 2414-2419.

Rosas-Ballina, M., et al. (2008). "Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia." Proceedings of the National Academy of Sciences of the United States of America 105(31): 11008-11013.

d.  Sundman, E. and P. S. Olofsson (2014). "Neural control of the immune system." Advances in Physiology Education 38(2): 135-139.

Chavan, S. S. and K. J. Tracey (2017). "Essential Neuroscience in Immunology." Journal of Immunology 198(9): 3389-3397.

Henley CE, Ivins D, Mills M, Wen FK, Benjamin BA. Osteopathic manipulative treatment and its relationship to autonomic nervous system activity as demonstrated by heart rate variability: a repeated measures study. Osteopath Med Prim Care. 2008 Jun 5;2:7. doi: 10.1186/1750-4732-2-7. PMID: 18534024; PMCID: PMC2442110.

Carnevali L, Lombardi L, Fornari M, Sgoifo A. Exploring the Effects of Osteopathic Manipulative Treatment on Autonomic Function Through the Lens of Heart Rate Variability. Front Neurosci. 2020 Oct 7;14:579365. doi: 10.3389/fnins.2020.579365. PMID: 33117124; PMCID: PMC7575744

Ruffini N, D'Alessandro G, Mariani N, Pollastrelli A, Cardinali L, Cerritelli F. Variations of high frequency parameter of heart rate variability following osteopathic manipulative treatment in healthy subjects compared to control group and sham therapy: randomized controlled trial. Front Neurosci. 2015 Aug 4;9:272. doi: 10.3389/fnins.2015.00272. PMID: 26300719; PMCID: PMC4523739.

Fornari M, Carnevali L, Sgoifo A. Single Osteopathic Manipulative Therapy Session Dampens Acute Autonomic and Neuroendocrine Responses to Mental Stress in Healthy Male Participants. J Am Osteopath Assoc. 2017 Sep 1;117(9):559-567. doi: 10.7556/jaoa.2017.110. PMID: 28846122.

Cerritelli F, Chiacchiaretta P, Gambi F, Saggini R, Perrucci MG, Ferretti A. Osteopathy modulates brain-heart interaction in chronic pain patients: an ASL study. Sci Rep. 2021 Feb 25;11(1):4556. doi: 10.1038/s41598-021-83893-8. PMID: 33633195; PMCID: PMC7907192.

Żurowska A, Malak R, Kołcz-Trzęsicka A, Samborski W, Paprocka-Borowicz M. Compression of the Fourth Ventricle Using a Craniosacral Osteopathic Technique: A Systematic Review of the Clinical Evidence. Evid Based Complement Alternat Med. 2017;2017:2974962. doi: 10.1155/2017/2974962. Epub 2017 Oct 18. PMID: 29234380; PMCID: PMC5664229.

Ventureyra, E. C. (2000). "Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept." Child's Nervous System 16(2): 101-102.

Howland, R. H. (2014). "Vagus Nerve Stimulation." Curr Behav Neurosci Rep 1(2): 64-73.

Dietrich, S., et al. (2008). "[A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI]." Biomedizinische Technik 53(3): 104-111.

Das, U. N. (2007). "Vagus nerve stimulation, depression, and inflammation." Neuropsychopharmacology 32(9): 2053-2054.

Miller, M. C. (2006). "What is vagus nerve stimulation?" Harvard Mental Health Letter 22(7): 8.

Buschman, H. P., et al. (2006). "Heart rate control via vagus nerve stimulation." Neuromodulation 9(3): 214-220.

Hirsch, E. F. (1962). "Innervation of the human heart. III. The conductive system." Archives of Pathology 74: 427-439.

Voss, A., et al. (2015). "Short-term heart rate variability--influence of gender and age in healthy subjects." PloS One 10(3): e0118308.

Mion, F., Pellissier, S., Garros, A., Damon, H., Roman, S., & Bonaz, B. (2020). Transcutaneous auricular vagus nerve stimulation for the treatment of irritable bowel syndrome: a pilot, open-label study. Bioelectronics in Medicine.doi:10.2217/bem-2020-0004

Grolaux P.J.D. (2019). Transcutaneous Vagus Nerve Stimulation in Private Healthcare Center: A Small-Scale Investigation Targeting Anxiety, Irritable Bowel Syndrome and Chronic Pain. J Neurol Neuromed 4(5): 7-22