Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-Immune System (NEIS). Part 2 - Webinar (2)

For the first time in the Maritimes, Pascal Grolaux, DO, BSc, MOst. will offer the original, evidence-based and most comprehensive  course, so far proposed in Canada and in Europe, on the Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS).

OBJECTIVES

This course will give an overview of general principles of neurophysiology, neuroanatomy of the central and autonomic nervous system, neuro-endocrine-immunology, general principles of inflammation and diseases, the brain-gut and brain-heart axis connection.

At the end of the course “Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 1”, the participant will be able to:

• Understand the global function of the Autonomic Nervous System with emphasis on the Vagus nerve.
• Understand the link between the vagus nerve and its relations to the neuroendocrine-immune system
• Understand the principles of inflammation linked to neuroendocrine-immunology
• Understand the role of the central autonomic network (CAN) and the brain structures and functions linked to it
• Understand the importance of the Brain-GUT and Brain-Heart axis

At the end of the course "“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 2”, the partiipant will be able to:

• Understand the essentials relationships with cranial nerve V, VII, IX and the Vagus nerve
• Understand the Blood-Brain-Barrier related to immunology
• Understand the role of the Glia in immune responses
• Understand the importance of the Gateway relfexes in immunology
• Understand the role of the key neurohormones in immunology
• Understand the principles of Heart Rate Variability Analysis based on a 3-lead EKG

This hybrid course is divided in 3 disctinctive parts.

Who Should Attend This Course

This course is designed for Osteopaths, Osteopathic students, Physiotherapists, Naturopaths, med. Doctors, other Health Practitioners (if you are not sure this course is for you, please contact us)

• Part 1 and Part 2 are webinars (theory only) for all participants.
• Part 3 will be onsite 4 days practice only and is divided two possibilities (2 days each) 1. Applied osteopathic treatment (only for Osteopathic manual practitioner, last yer students of Osteopathy). 2. Non-invasive vagus nerve (tVNS) and trigeminal nerve stimulation (tTMS) (for Osteopathic manual practitioner, last year students of Osteopathy and other Health Professionals).

Note that only Osteopathic manual practitioner and last year students of Osteopathy can enroll to the 4 days practice (OMT and tVNS-tTMS)!

FULL COURSE HYBRID PROGRAM

I: First Webinar (Theory): 3 days with 5hours each

“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 1”

·  Type: Live webinar recorded for further use

·  Language: English

·  Participants: Osteopath, Osteopathic students, Physiotherapists, Naturopaths, med. Doctors, other Health Practitioners

·  Date: 18.-20 November 2022

·  Duration: 3 days, 5 hours each day

·  Schedule: 14:00-19:00 pm, local time

·  Cancellation deadline: 4 weeks before

·  Precondition for practical course “Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System” and/or “Osteopathic Approach Targeting the Vagus nerve and the Neuroendocrine-immune system”

Content Webinar Part 1:

•  ANATOMOPHYSIOLOGY; AUTONOMIC NERVOUS SYSTEM

•  ANATOMOPHYSIOLOGY; VAGUS NERVE

•  HEART-BRAIN AXIS

•  GUT-BRAIN AXIS

•  LIMBIC SYSTEM

•  CENTRAL AUTONOMIC NETWORK

•  NEURO-IMMUNOLOGY

•  COMMON MECHANISMS OF DISEASES AND THE VAGUS NERVE

II: Second Webinar (Theory): 3days with 5hours each

“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 2”

·  Type: Live webinar recorded for further use

·  Language: English

·  Participants: Osteopath, Osteopathic students, Physiotherapists, Naturopaths, med. Doctors

·  Date : 20-22 January 2023

·  Duration: 3 days with 5 hours each (one additional hour might be required)

·  Schedule: 14:00-19:00 pm, local time

·  Cancellation deadline: 4 weeks before

·  Prerequisite: “Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 1”

·  Precondition for practical course “Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System” and/or “Osteopathic Approach Targeting the Vagus nerve and the Neuroendocrine-immune system”

Content Webinar Part 2:

•  APPLIED ANATOMY : CRANIAL NERVES V, VII et IX

•  INFLAMMATION AND THE BLOOD BRAIN BARRIER

•  GLIA: IMMUNE RESPONSE

•  THE GATEWAY REFLEXES

•  NEUROHORMONES IN IMMUNOLOGY

•  HEART RATE VARIABILITY: PRINCIPLES AND ANALYSIS

III: Practical course: 3 days

„Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System “

·  Type: Practical course at IOSR

·  Language: English

·  Participants: Osteopath, Osteopathic students, Physiotherapists, Naturopaths, med. Doctors, other Health Practitioners

·  Date : 

·  Duration: 3 full days

·  Schedule: 2-4 June 2023 Friday/Saturday/Sunday. (9AM-5PM)

·  Cancellation deadline: 4 weeks before course

·  Precondition: Webinar Part 1 and Part 2 must have been completed

Content

•  Practical: ECG is not prerequisite but recommended.

•  Theory: History/principles of Neuromodulation

•  Neuromodulation - demonstration: X, V

•  Scientific evidences and indications of non-invasive vagus and the trigeminal  nerve stimulation (nVNS and nTNS)

•  Heart rate variability and assessment of the sympatho-vagal balance via short-term 3 leads ECG, analysis via Kubios software.

•  Vagus nerve and trigeminal nerve stimulation : indications and contraindications

•  Vagus nerve and trigeminal nerve stimulation : exercices

•  HRV analysis exercices before and after stimulation

•  Treatment protocols for nVNS and nTNS: case review and exercise

•  Other natural means to stimulate the vagus and trigeminal nerves

•  Discussion

III: Practical course: 3 days

Osteopathic Approach Targeting the Vagus nerve and the Neuroendocrine-immune system

·  Type: Practical course at IOSR

·  Language: English

·  Participants: Osteopath, Osteopathic students

·  Date : 19-21 May 2023

·  Duration: 3 full days

·  Schedule:  Friday/Saturday/Sunday: 9AM-5PM

·  Cancellation deadline: 4 weeks before course

·  Precondition: Webinar 1 and 2 must have been completed

Content:

•  Practical: ECG is not prerequisite but recommended.

·  Philosophy and Principles behind the NEI osteopathic treatment approach

·  The Osteopathic Centers

·  Applied General and Specific Osteopathic approaches/techniques evaluated by ECG/HRV analysis

·  Heart rate variability (with Kubios software) and assessment of the sympatho-vagal balance via short-term 3 leads ECG, before and after the treatment

·  Other natural means to stimulate the vagus and trigeminal nerves

·  Discussion

SELECTED READINGS

Tracey, K. J. (2002). "The inflammatory reflex." Nature 420(6917): 853-859.

Hosoi, T. and Y. Nomura (2004). "Functional role of acetylcholine in the immune system." Frontiers in Bioscience 9: 2414-2419.

Rosas-Ballina, M., et al. (2008). "Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia." Proceedings of the National Academy of Sciences of the United States of America 105(31): 11008-11013.

d.  Sundman, E. and P. S. Olofsson (2014). "Neural control of the immune system." Advances in Physiology Education 38(2): 135-139.

Chavan, S. S. and K. J. Tracey (2017). "Essential Neuroscience in Immunology." Journal of Immunology 198(9): 3389-3397.

Henley CE, Ivins D, Mills M, Wen FK, Benjamin BA. Osteopathic manipulative treatment and its relationship to autonomic nervous system activity as demonstrated by heart rate variability: a repeated measures study. Osteopath Med Prim Care. 2008 Jun 5;2:7. doi: 10.1186/1750-4732-2-7. PMID: 18534024; PMCID: PMC2442110.

Carnevali L, Lombardi L, Fornari M, Sgoifo A. Exploring the Effects of Osteopathic Manipulative Treatment on Autonomic Function Through the Lens of Heart Rate Variability. Front Neurosci. 2020 Oct 7;14:579365. doi: 10.3389/fnins.2020.579365. PMID: 33117124; PMCID: PMC7575744

Ruffini N, D'Alessandro G, Mariani N, Pollastrelli A, Cardinali L, Cerritelli F. Variations of high frequency parameter of heart rate variability following osteopathic manipulative treatment in healthy subjects compared to control group and sham therapy: randomized controlled trial. Front Neurosci. 2015 Aug 4;9:272. doi: 10.3389/fnins.2015.00272. PMID: 26300719; PMCID: PMC4523739.

Fornari M, Carnevali L, Sgoifo A. Single Osteopathic Manipulative Therapy Session Dampens Acute Autonomic and Neuroendocrine Responses to Mental Stress in Healthy Male Participants. J Am Osteopath Assoc. 2017 Sep 1;117(9):559-567. doi: 10.7556/jaoa.2017.110. PMID: 28846122.

Cerritelli F, Chiacchiaretta P, Gambi F, Saggini R, Perrucci MG, Ferretti A. Osteopathy modulates brain-heart interaction in chronic pain patients: an ASL study. Sci Rep. 2021 Feb 25;11(1):4556. doi: 10.1038/s41598-021-83893-8. PMID: 33633195; PMCID: PMC7907192.

Żurowska A, Malak R, Kołcz-Trzęsicka A, Samborski W, Paprocka-Borowicz M. Compression of the Fourth Ventricle Using a Craniosacral Osteopathic Technique: A Systematic Review of the Clinical Evidence. Evid Based Complement Alternat Med. 2017;2017:2974962. doi: 10.1155/2017/2974962. Epub 2017 Oct 18. PMID: 29234380; PMCID: PMC5664229.

Ventureyra, E. C. (2000). "Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept." Child's Nervous System 16(2): 101-102.

Howland, R. H. (2014). "Vagus Nerve Stimulation." Curr Behav Neurosci Rep 1(2): 64-73.

Dietrich, S., et al. (2008). "[A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI]." Biomedizinische Technik 53(3): 104-111.

Das, U. N. (2007). "Vagus nerve stimulation, depression, and inflammation." Neuropsychopharmacology 32(9): 2053-2054.

Miller, M. C. (2006). "What is vagus nerve stimulation?" Harvard Mental Health Letter 22(7): 8.

Buschman, H. P., et al. (2006). "Heart rate control via vagus nerve stimulation." Neuromodulation 9(3): 214-220.

Hirsch, E. F. (1962). "Innervation of the human heart. III. The conductive system." Archives of Pathology 74: 427-439.

Voss, A., et al. (2015). "Short-term heart rate variability--influence of gender and age in healthy subjects." PloS One 10(3): e0118308.

Mion, F., Pellissier, S., Garros, A., Damon, H., Roman, S., & Bonaz, B. (2020). Transcutaneous auricular vagus nerve stimulation for the treatment of irritable bowel syndrome: a pilot, open-label study. Bioelectronics in Medicine.doi:10.2217/bem-2020-0004

Grolaux P.J.D. (2019). Transcutaneous Vagus Nerve Stimulation in Private Healthcare Center: A Small-Scale Investigation Targeting Anxiety, Irritable Bowel Syndrome and Chronic Pain. J Neurol Neuromed 4(5): 7-22