Integrative Approach Targeting the Vagus Nerve and the NEI System (NEIS). 2d Ed. Part 4. Neuromodulation

Pascal JD Grolaux, BSc, DO, MOst. Dr. (hon) ACoPM will offer the unique, evidence-based and most comprehensive course, so far proposed in Canada and in Europe, on the Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS), including Heart Rate Variability analysis based on short-term EKG and learning on bioelectronic medicine (non-invasive vagus nerve and trigeminal nerve stimulation based on latest scientific evidences).

Important Note

• Part 4 will be onsite, 2 days practice only. Non-invasive vagus nerve (tVNS) and trigeminal nerve stimulation (tTMS) (for Osteopathic manual practitioner, and other Health Professionals).

Note that only Osteopathic manual practitioner can ONLY enroll to the 4 days practice (OMT and tVNS-tTMS)!

TOTAL CEUs EARNED : 14.5 hours

Note: language will be English with French translation if needed.

OBJECTIVES

The Part 4 (IIIb) "Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System " (onsite-practice only) (only for those who have followed the Part 1 and Part 2), will introduce to non-invasive neuromodulation of the vagus nerve (nVNS or tVNS) and the trigeminal nerve (nTNS or tTNS). We will see how proper neuromodulation of these nerves affects the heart rate variability (HRV) analysis as a biomarker of the sympatho-vagal balance and more globally affects the psychophysiology and the general physiology.

At the end of the course "“Integrative Approach Targeting the Vagus Nerve and the Neuroendocrine-immune System (NEIS). Part 4 ”Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System ", the participant will:

• Understand the principles of neuromodulation and biolectronic medicine
• Understand the how to neuro-modulate the vagus and the trigemnial nerve
• Understand the indications and contra-indications of stimulating theses nerves
• Understand the different parameters and stite of stimulation and their neuroendocrine-immune effects
• Understand different possible neuromodulation treatment protocols and assessment/follow-up protocols
• Be able to practice HRV analysis on short-term EKG-based and demonstrate the effects of vagal and trigeminal neuromodulation on HRV
• Be able to demonstrate their skills in HRV analysis
• Be able to offer a patient an evidence-based treatment plan and assessment plan (based on HRV analysis)

Who Should Attend This Course

This course is designed for Osteopaths, other Health Practitioners who has followed the previous Part 1 and Part 2 of the course.

Practical course: 2 days on site (Please note the dates)

„Bioelectronic Neuromodulation Targeting the Vagus and Trigeminal nerves, and the Neuroendocrine-immune System “

·  Type: Practical course at IOSR (Truro clinic)

·  Language: English with French translation available

·  Participants: Osteopath, other Health Practitioners

·  Date : 21-22 April 2024

·  Duration: 2 full days

·  Schedule: Sunday/Monday. (9AM-5PM)

·  Cancellation deadline: 4 weeks before course

·  Precondition: Webinar Part 1 and Part 2 must have been completed

Content Practice Part 4:

• Practical: ECG is not prerequisite but recommended.
• Practical: Kubios software pre-installed on PC/Mac is not prerequisite but recommended
• Theory: History/principles of Neuromodulation
• Neuromodulation - demonstration: Vagus and Trigeminal nerves
• Scientific evidences and indications of non-invasive vagus and the trigeminal  nerve stimulation (nVNS and nTNS)
• Heart rate variability and assessment of the sympatho-vagal balance via short-term 3 leads ECG, analysis via Kubios software.
• Vagus nerve and trigeminal nerve stimulation : indications, contraindications, safety and tolerance
• Vagus nerve and trigeminal nerve stimulation : exercices
• HRV analysis exercices before and after stimulation
• Treatment protocols for nVNS and nTNS: case review
• Other natural means to stimulate the neuroendocrine-immune system, the vagus and trigermeminal nerves
• Discussion

SELECTED READINGS

Tracey, K. J. (2002). "The inflammatory reflex." Nature 420(6917): 853-859.

Hosoi, T. and Y. Nomura (2004). "Functional role of acetylcholine in the immune system." Frontiers in Bioscience 9: 2414-2419.

Rosas-Ballina, M., et al. (2008). "Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia." Proceedings of the National Academy of Sciences of the United States of America 105(31): 11008-11013.

d.  Sundman, E. and P. S. Olofsson (2014). "Neural control of the immune system." Advances in Physiology Education 38(2): 135-139.

Chavan, S. S. and K. J. Tracey (2017). "Essential Neuroscience in Immunology." Journal of Immunology 198(9): 3389-3397.

Ventureyra, E. C. (2000). "Transcutaneous vagus nerve stimulation for partial onset seizure therapy. A new concept." Child's Nervous System 16(2): 101-102.

Howland, R. H. (2014). "Vagus Nerve Stimulation." Curr Behav Neurosci Rep 1(2): 64-73.

Dietrich, S., et al. (2008). "[A novel transcutaneous vagus nerve stimulation leads to brainstem and cerebral activations measured by functional MRI]." Biomedizinische Technik 53(3): 104-111.

Das, U. N. (2007). "Vagus nerve stimulation, depression, and inflammation." Neuropsychopharmacology 32(9): 2053-2054.

Miller, M. C. (2006). "What is vagus nerve stimulation?" Harvard Mental Health Letter 22(7): 8.

Buschman, H. P., et al. (2006). "Heart rate control via vagus nerve stimulation." Neuromodulation 9(3): 214-220.

Hirsch, E. F. (1962). "Innervation of the human heart. III. The conductive system." Archives of Pathology 74: 427-439.

Voss, A., et al. (2015). "Short-term heart rate variability--influence of gender and age in healthy subjects." PloS One 10(3): e0118308.

Mion, F., Pellissier, S., Garros, A., Damon, H., Roman, S., & Bonaz, B. (2020). Transcutaneous auricular vagus nerve stimulation for the treatment of irritable bowel syndrome: a pilot, open-label study. Bioelectronics in Medicine.doi:10.2217/bem-2020-0004

Grolaux P.J.D. (2019). Transcutaneous Vagus Nerve Stimulation in Private Healthcare Center: A Small-Scale Investigation Targeting Anxiety, Irritable Bowel Syndrome and Chronic Pain. J Neurol Neuromed 4(5): 7-22

Pascal J.D. Grolaux. Effects of Chronic Non-Invasive Vagus Nerve Stimulation in an Asplenic Individual with Rheumatoid Arthritis: Report from an n-of-1 Study., 12 April 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1546549/v1]